{"id":3553,"date":"2023-03-09T14:39:20","date_gmt":"2023-03-09T14:39:20","guid":{"rendered":"https:\/\/covid19.seimc.org\/?page_id=3553"},"modified":"2026-01-30T09:53:53","modified_gmt":"2026-01-30T09:53:53","slug":"susceptibilidad-de-la-variante-omicron-a-los-anticuerpos-monoclonales-y-otros-antivirales","status":"publish","type":"page","link":"https:\/\/covid19.seimc.org\/index.php\/susceptibilidad-de-la-variante-omicron-a-los-anticuerpos-monoclonales-y-otros-antivirales\/","title":{"rendered":"Susceptibilidad de la variante \u00f3micron a los anticuerpos monoclonales y otros antivirales"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3553\" class=\"elementor elementor-3553\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-87d15df elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"87d15df\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d0ccd72\" data-id=\"d0ccd72\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2343b5a elementor-widget-mobile__width-auto elementor-widget elementor-widget-heading\" data-id=\"2343b5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Susceptibilidad de la variante \u00f3micron a los anticuerpos monoclonales y otros antivirales<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec7467e elementor-align-right elementor-widget elementor-widget-button\" data-id=\"ec7467e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-md\" href=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/SEIMC-Susceptibilidad-de-la-variante-omicron-a-los-anticuerpos-monoclonales-y-otros-antivirales_Marzo2023.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">descargar pdf<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0a57357 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0a57357\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b3b8345\" data-id=\"b3b8345\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c601c2c elementor-widget elementor-widget-text-editor\" data-id=\"c601c2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Las mutaciones en la prote\u00edna Spike de \u00f3micron hacen que, in vitro, esta variante sea resistente a la pr\u00e1ctica totalidad de los anticuerpos monoclonales (Tabla 1).<\/p><p>En cambio, es esperable que \u00f3micron siga siendo susceptible a antivirales de mol\u00e9cula peque\u00f1a como el inhibidor de proteasa CL3, nirmatrelvir (Paxlovid<sup>\u00ae<\/sup>, Pfizer), el an\u00e1logo a ribonucle\u00f3sidos, molnupiravir (MSD), y el inhibidor de la polimerasa, remdesivir (Veklury<sup>\u00ae<\/sup>, Gilead Sciences).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8377122 elementor-widget elementor-widget-text-editor\" data-id=\"8377122\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h5><span style=\"color: #ffffff;\">Tabla 1<\/span><\/h5><p style=\"color: #ffffff;\"><b>Susceptibilidad in vitro de las variantes virales a los anticuerpos monoclonales.<\/b><br \/><em>Veces que se reduce la susceptibilidad a la neutralizaci\u00f3n (fold change)<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b58f04 elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"4b58f04\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1952\" height=\"1225\" src=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_1.jpg\" class=\"attachment-full size-full wp-image-3570\" alt=\"\" srcset=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_1.jpg 1952w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_1-300x188.jpg 300w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_1-1024x643.jpg 1024w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_1-768x482.jpg 768w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_1-1536x964.jpg 1536w\" sizes=\"(max-width: 1952px) 100vw, 1952px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-034294e elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-image\" data-id=\"034294e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1170\" height=\"1225\" src=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_1.jpg\" class=\"attachment-full size-full wp-image-3581\" alt=\"\" srcset=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_1.jpg 1170w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_1-287x300.jpg 287w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_1-978x1024.jpg 978w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_1-768x804.jpg 768w\" sizes=\"(max-width: 1170px) 100vw, 1170px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a76701a elementor-widget elementor-widget-text-editor\" data-id=\"a76701a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6><em>Tabla 1 (continuaci\u00f3n)<\/em><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2d3dd47 elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-image\" data-id=\"2d3dd47\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1084\" height=\"1225\" src=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_2.jpg\" class=\"attachment-full size-full wp-image-3590\" alt=\"\" srcset=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_2.jpg 1084w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_2-265x300.jpg 265w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_2-906x1024.jpg 906w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_2-768x868.jpg 768w\" sizes=\"(max-width: 1084px) 100vw, 1084px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f0b60a elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-text-editor\" data-id=\"0f0b60a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6><em>Tabla 1 (continuaci\u00f3n)<\/em><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c384427 elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-image\" data-id=\"c384427\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1226\" src=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_3.jpg\" class=\"attachment-full size-full wp-image-3589\" alt=\"\" srcset=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_3.jpg 1024w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_3-251x300.jpg 251w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_3-855x1024.jpg 855w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_3-768x920.jpg 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-007f86b elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-text-editor\" data-id=\"007f86b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6><em>Tabla 1 (continuaci\u00f3n)<\/em><\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4fe418 elementor-hidden-desktop elementor-hidden-tablet elementor-widget elementor-widget-image\" data-id=\"c4fe418\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1114\" height=\"1226\" src=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_4.jpg\" class=\"attachment-full size-full wp-image-3588\" alt=\"\" srcset=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_4.jpg 1114w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_4-273x300.jpg 273w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_4-930x1024.jpg 930w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_movil_4-768x845.jpg 768w\" sizes=\"(max-width: 1114px) 100vw, 1114px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4fb4202 elementor-hidden-mobile elementor-widget elementor-widget-image\" data-id=\"4fb4202\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1824\" height=\"1226\" src=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_2.jpg\" class=\"attachment-full size-full wp-image-3569\" alt=\"\" srcset=\"https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_2.jpg 1824w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_2-300x202.jpg 300w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_2-1024x688.jpg 1024w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_2-768x516.jpg 768w, https:\/\/covid19.seimc.org\/wp-content\/uploads\/2023\/03\/tabla_variante_2-1536x1032.jpg 1536w\" sizes=\"(max-width: 1824px) 100vw, 1824px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-42a49a4 elementor-widget elementor-widget-text-editor\" data-id=\"42a49a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h6>El esquema de colores indica la reducci\u00f3n en la neutralizaci\u00f3n:\n<ul>\n \t<li>ausencia de color: susceptibilidad reducida &lt;5 veces<\/li>\n \t<li>naranja claro: susceptibilidad reducida de 5 a 24,9 veces<\/li>\n \t<li>naranja oscuro: susceptibilidad reducida \u226525 veces<\/li>\n<\/ul><\/h6>\n<h6>Fuente: <a href=\"https:\/\/covdb.stanford.edu\/page\/susceptibility-data\/\" target=\"_blank\" rel=\"noopener\">Stanford University Coronavirus Antiviral &amp; Resistance Database<\/a><\/h6>\n<h6>\u2022 El valor de fold change es la mediana del valor de las muestras, el sub\u00edndice indica el n\u00famero de muestras.\n&#8211; : ausencia de datos de susceptibilidad.\n* : conflicto entre datos de grupos de investigaci\u00f3n.<\/h6>\n<h6>\u2022 Abreviaturas de los anticuerpos monoclonales (mAb): BAM: Bamlanivimab\/LY-CoV555; CAS: Casirivimab \/ REGN10933; IMD: Imdevimab \/ REGN10987; CAS\/IMD: Casirivimab+imdevimab \/ REGN-COV2; ETE: Etesevimab\/LY-CoV016\/JS016\/CB6; CIL: Cilgavimab\/COV2-2130\/AZD1061; TIX: Tixagevimab \/ COV2-2196 \/ AZD8895; TIX\/CIL: Tixagevimab+Cilgavimab; BAM\/ETE: Bamlanivimab+Etesevimab; SOT: Sotrovimab \/ Vir-7831 \/ S309; REG: Regdanvimab \/ CT-P59.<\/h6>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8132d7c elementor-widget elementor-widget-text-editor\" data-id=\"8132d7c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: right;\"><span style=\"font-size: 19.2px; text-align: right;\">Actualizado: 10 marzo 2023<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Susceptibilidad de la variante \u00f3micron a los anticuerpos monoclonales y otros antivirales descargar pdf Las mutaciones en la prote\u00edna Spike de \u00f3micron hacen que, in vitro, esta variante sea resistente a la pr\u00e1ctica totalidad de los anticuerpos monoclonales (Tabla 1). En cambio, es esperable que \u00f3micron siga siendo susceptible a antivirales de mol\u00e9cula peque\u00f1a como [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3553","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/covid19.seimc.org\/index.php\/wp-json\/wp\/v2\/pages\/3553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/covid19.seimc.org\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/covid19.seimc.org\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/covid19.seimc.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/covid19.seimc.org\/index.php\/wp-json\/wp\/v2\/comments?post=3553"}],"version-history":[{"count":3,"href":"https:\/\/covid19.seimc.org\/index.php\/wp-json\/wp\/v2\/pages\/3553\/revisions"}],"predecessor-version":[{"id":4221,"href":"https:\/\/covid19.seimc.org\/index.php\/wp-json\/wp\/v2\/pages\/3553\/revisions\/4221"}],"wp:attachment":[{"href":"https:\/\/covid19.seimc.org\/index.php\/wp-json\/wp\/v2\/media?parent=3553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}